|
|
| CAS No. | 75330-75-5 |
| Chemical Name: | Lovastatin |
| Synonyms: | msd803;mevlor;MK-803;Sivlor;LOVALIP;MEVACOR;Paschol;Rovacor;LOVASTIN;MEVINOLIN |
| CBNumber: | CB7169342 |
| Molecular Formula: | C24H36O5 |
| Formula Weight: | 404.54 |
| MOL File: | 75330-75-5.mol |
|
|
|
|
| Lovastatin Property |
|
|
| refractive index : |
320 ° (C=0.5, CH3CN) |
|
|
|
| Water Solubility : |
0.0004 mg/mL at 25 ºC |
|
|
|
|
|
| EPA Substance Registry System: |
Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7, 8,8a-hexahydro-3,7-dimethyl- 8-[2-[(2R,4R)-tetrahydro- 4-hydroxy-6-oxo-2H-pyran- 2-yl]ethyl]-1-naphthalenyl ester, (2S)-(75330-75-5) |
|
|
Lovastatin Chemical Properties,Usage,Production |
a cholesterol lowering agent
Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.
After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.
|
|
Chemical Properties
White Solid |
|
Usage
An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase |
|
|
|
Usage
Lovastatin (mevinolin) is a metabolite first isolated from Monascus ruber and later found in several other fungal species. Lovastatin is a potent inhibitor of HMG-CoA. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. Lovastatin was developed as a drug as a hypolipemic agent. |
|
Usage
anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor |
|
|
|
Biological Activity
Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro . |
|
|
| Lovastatin Suppliers Global( 246)Suppliers |
|
|
|
|
|
|
)ethyl]-1-naphthalenylester
[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,
1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty
2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci
3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl
3r,7s,8s,8ar)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[2r,4r)-tetrahydro-(1
4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r*),3
4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate
mevlor
msd803
oxy)-1-naphthaleneheptanoicaciddelta-lactone
LOVASTATION
LOVASTIN
LOVALIP
LOVASTATIN
MEVINOLIN
MEVACOR
MEVINACOR
(2S)-(1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYL-2-METHYL BUTANOATE
2BETA,6ALPHA-DIMETHYL-8ALPHA-(2-METHYL-1-OXOBUTOXY)MEVINIC ACID LACTONE
BioChemical
Biochemicals and Reagents
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate
6-A-METHYLCOMPACTIN
6ALPHA-METHYLCOMPACTIN
75330-75-5
MONACOLIN K
MK-803
(S)-2-METHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
Hydroxymethylglutaryl-CoA Reductase
Enzymes, Inhibitors, and Substrates
Enzyme Inhibitors by Enzyme
Enzyme Inhibitors
D to K
Lovastatin USP24
LOVASTATIN MM(CRM STANDARD)
LOVASTATIN USP(CRM STANDARD)
RedYeastRice
LovastatinC24H3605
Lovastatine
C24H36O5
MK-803, Lovalip, Mevacor, Mevinacor
Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester, (2S)-
2-methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid
mevinolin from aspergillus sp.
LOVASTATIN(PATENT-NOSUPPLY)
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate
MEVINOLIN / LOVASTATIN / MK-803
Antibiotics
LOVASTATIN,MEVINOLIN
APIs
(S)-((1S,3R,7S,8S,8AR)-8-(2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-2H-PYRAN-2-YL)ETHYL)-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL) 2-METHYLBUTANOATE
Intermediates & Fine Chemicals
Pharmaceuticals
API's
Sivlor
[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactone
|