| Company Name: | Guangzhou Isun Pharmaceutical Co., Ltd Gold |
| Tel: | 020-39119399 18927568969 |
| Email: | isunpharm@qq.com, isunpharm@hotmail.com |
| Products Intro: |
Product Name:Mevinolin
CAS:75330-75-5
Purity:BR Package:5Mg;50Mg;250Mg;1g |
| Company Name: | J & K SCIENTIFIC LTD. |
| Tel: | 400-666-7788 +86-10-82848833 |
| Email: | jkinfo@jkchemical.com;market3@jkchemical.com |
| Products Intro: |
Product Name:Lovastatin
CAS:75330-75-5
Purity:97% Package:100MG,25MG |
| Company Name: | Meryer (Shanghai) Chemical Technology Co., Ltd. |
| Tel: | +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing) |
| Email: | sh@meryer.com |
| Products Intro: |
Product Name:Lovastatin
CAS:75330-75-5
Purity:>98.0%(LC) Package:5g;25g Remarks:L0214 |
| Company Name: | 3B Pharmachem (Wuhan) International Co.,Ltd. |
| Tel: | 86-21-50328103 * 801、802、803、804 Mobile:18930552037 |
| Email: | 67055399@qq.com |
| Products Intro: |
Product Name:Lovastatin;(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-diMethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-Methylbutanoate
CAS:75330-75-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g |
|
| Product Name: | Lovastatin | | Synonyms: | )ethyl]-1-naphthalenylester;[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci;3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl;3r,7s,8s,8ar)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[2r,4r)-tetrahydro-(1;4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r*),3;4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate | | CAS: | 75330-75-5 | | MF: | C24H36O5 | | MW: | 404.54 | | EINECS: | | | Product Categories: | Antibiotics;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;HMG-CoA reductase;Chiral Reagents;Heterocycles;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Isotopically Labeled Pharmaceutical Reference Standard;RYTHYMOL;antibiotic;Cardiovascular APIs | | Mol File: | 75330-75-5.mol |  |
| | Lovastatin Chemical Properties |
| mp | 175°C | | refractive index | 320 ° (C=0.5, CH3CN) | | storage temp. | 2-8°C
| | Water Solubility | 0.0004 mg/mL at 25 ºC | | Merck | 5586 | | CAS DataBase Reference | 75330-75-5(CAS DataBase Reference) | | EPA Substance Registry System | Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7, 8,8a-hexahydro-3,7-dimethyl- 8-[2-[(2R,4R)-tetrahydro- 4-hydroxy-6-oxo-2H-pyran- 2-yl]ethyl]-1-naphthalenyl ester, (2S)-(75330-75-5) |
| | Lovastatin Usage And Synthesis |
| a cholesterol lowering agent | Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.
After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.
| | Chemical Properties | White Solid | | Usage | An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase | | Usage | antiarrhythmic | | Usage | Lovastatin (mevinolin) is a metabolite first isolated from Monascus ruber and later found in several other fungal species. Lovastatin is a potent inhibitor of HMG-CoA. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. Lovastatin was developed as a drug as a hypolipemic agent. | | Usage | anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor | | Usage | Cardiovascular | | Biological Activity | Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro . |
| | Lovastatin Preparation Products And Raw materials |
|