| Identification | More | 【Name】
Lovastatin | 【CAS】
75330-75-5 | 【Synonyms】
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate
2BETA,6ALPHA-DIMETHYL-8ALPHA-(2-METHYL-1-OXOBUTOXY)MEVINIC ACID LACTONE
(2S)-(1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENYL-2-METHYL BUTANOATE
6ALPHA-METHYLCOMPACTIN
6-A-METHYLCOMPACTIN
LOVALIP
LOVASTATIN
LOVASTATION
LOVASTIN
MEVACOR
MEVINACOR
MEVINOLIN
MK-803
MONACOLIN K
(S)-2-METHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
)ethyl]-1-naphthalenylester
[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,
1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty
2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci
3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl | 【Molecular Formula】
C24H36O5 | 【MDL Number】
MFCD00072164 | 【Molecular Weight】
404.54 | 【MOL File】
75330-75-5.mol |
| Questions And Answer | Back Directory | 【a cholesterol lowering agent】
Lovastatin is a cholesterol lowering agent isolated from a strain of Aspergillus terreus.
Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.
After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.
|
| Safety Data | Back Directory | 【Hazard Codes 】
Xi | 【Risk Statements 】
R36/37/38:Irritating to eyes, respiratory system and skin . | 【Safety Statements 】
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | 【RIDADR 】
3077 | 【WGK Germany 】
3
| 【RTECS 】
EK7907000
| 【HazardClass 】
9 | 【PackingGroup 】
III | 【Hazardous Substances Data】
75330-75-5(Hazardous Substances Data) |
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