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| CAS No. | 80890-47-7 |
| Chemical Name: | CONCANAMYCIN A |
| Synonyms: | S-45A;A661-I;x4357b;FOLIMYCIN;NSC 674620;CONCANAMYCIN A;A,ConcanaMycin;Antibiotic S-45A;Antibiotic A661I;antibioticx4357b |
| CBNumber: | CB9696475 |
| Molecular Formula: | C46H75NO14 |
| Formula Weight: | 866.09 |
| MOL File: | 80890-47-7.mol |
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| CONCANAMYCIN A Property |
| mp : |
179-180℃ (dichloromethane ethanol ) |
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CONCANAMYCIN A Chemical Properties,Usage,Production |
Usage
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. |
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Biological Activity
Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. |
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| CONCANAMYCIN A Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| CONCANAMYCIN A Suppliers Global( 28)Suppliers |
| Supplier | Tel | Fax | Email | Country | ProdList | Advantage |
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J & K SCIENTIFIC LTD.
| -- | -- | jkinfo@jkchemical.com;market3@jkchemical.com | CHINA |
96847
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76
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3B Pharmachem (Wuhan) International Co.,Ltd.
| 86-21-50328103 * 801、802、803、804 Mobile:18930552037 | 86-21-50328109 | 67055399@qq.com | CHINA |
15983
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69
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Dalian Meilun Biotech Co., Ltd.
| 0411-66771943；0411-66771942 | 0411-66771945 | sales@meilune.com | CHINA |
5010
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58
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ShangHai YuanYe Biotechnology Co., Ltd.
| 021-61312847 qq：2797782341 | 021-60137357 | 2797782341@qq.com | CHINA |
7597
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60
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
| 021-20337333/400-620-6333 | 021-50323701 | sale@aladdin-e.com | CHINA |
24330
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65
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Shanghai Ruji Biology Technology Co., Ltd.
| +86-21-65211385-8001 36031160 | +86-21-65211385-8004 | sales@shruji.com | CHINA |
3241
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55
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Shanghai Tauto Biotech Co., Ltd
| 0086-21-51320588 | 0086-21-51320502 | export2@tautobiotech.com | CHINA |
4011
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66
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Guangzhou Isun Pharmaceutical Co., Ltd
| 020-39119399 18927568969 | 020-39119999 | isunpharm@qq.com, isunpharm@hotmail.com | CHINA |
4836
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55
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Shanghai BeiZhuo Biotech Co., Ltd.
| 021-61119791/13386096464 | 021-50190009 | bzswkf@foxmail.com | CHINA |
3993
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50
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ChemStrong Scientific Co.,Ltd
| 0755 66853366 | 0755 28363542 | sales@chem-strong.com; | CHINA |
11269
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56
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antibioticx4357b
x4357b
80890-47-7
BioChemical
Antibiotics
Antibiotics A-F
Antibiotics A to Z
FOLIMYCIN
FOLIMYCIN, STREPTOMYCES SP
FOLIMYCIN, STREPTOMYCES SPECIES
CONCANAMYCIN A
CONCANAMYCIN A, STREPTOMYCES SP
concanamycin A from streptomyces species
C46H75NO14
A661-I
Antibiotic A661I
Antibiotic S-45A
S-45A
(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(AMinocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-Methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-Methylbutyl]-9-ethyl-8,10-
ConcanaMycin A (high purity)
A,ConcanaMycin
FoliMycin, TAN 1323B
NSC 674620
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