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CALPHOSTIN C

CAS No.121263-19-2
Chemical Name:CALPHOSTIN C
Synonyms:UCN-1028C;PKF 115-584;CALPHOSTIN C;Cladochrome E;Calphostin C,98%;(R)-Calphostin C;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384;Calphostin C(UCN 1028C, PKF 115584)
CBNumber:CB7457711
Molecular Formula:C44H38O14
Formula Weight:790.76
MOL File:121263-19-2.mol
CALPHOSTIN C Property
storage temp. : −20°C
solubility : DMF: 1 mg/mL
form : powder
color : red to brown
Safety
Hazard Codes : Xn
Risk Statements : 20/21/22-36/37/38
Safety Statements : 24/25-36-26
WGK Germany : 3
HS Code : 29209010

CALPHOSTIN C Chemical Properties,Usage,Production

Chemical Properties
Dark red solid
Usage
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.
Usage
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).
CALPHOSTIN C Preparation Products And Raw materials
Raw materials
Preparation Products
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121263-19-2(CALPHOSTIN C)Related Search:
9-METHYLPHENANTHRENE 1,7-DIMETHYLNAPHTHALENE 9-N-PROPYLPHENANTHRENE calphostin B 7-METHYL-2-NAPHTHOL 1-Naphthalenol,6-methyl-(9CI) 1,8-DIMETHYLPHENANTHRENE 4-Methoxyphenanthrene 4-Hydroxy-1-naphthaldehyde 2'-HYDROXY-1'-ACETONAPHTHONE 3-NAPHTHALEN-2-YL-PROPAN-1-OL 2-ISOPROPENYLNAPHTHALENE 4-PHENYL-2-BUTYL ACETATE 1,9-DIMETHYLPHENANTHRENE 9-ETHYLPHENANTHRENE 5-Methylnaphthalene-1-ol CALPHOSTIN C 1-ALLYLNAPHTHALENE
CALPHOSTIN C CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES 2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER BioChemical Cell Biology Cell Signaling and Neuroscience 121263-19-2 UCN-1028C Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Protein Kinase C (PKC) CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES C44H38O14 (R)-Calphostin C 1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione 4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione Calphostin C,98% Calphostin CUCN-1028C (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester Calphostin C(UCN 1028C, PKF 115584) C,CalphostinCfroMCladosporiuMcladosporioide UCN 1028 C, PKF 115-384 Cladochrome E PKF 115-584 He Ding C Carver Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer
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