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CAS No. | 121263-19-2 |
Chemical Name: | CALPHOSTIN C |
Synonyms: | UCN-1028C;PKF 115-584;CALPHOSTIN C;Cladochrome E;Calphostin C,98%;(R)-Calphostin C;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384;Calphostin C(UCN 1028C, PKF 115584) |
CBNumber: | CB7457711 |
Molecular Formula: | C44H38O14 |
Formula Weight: | 790.76 |
MOL File: | 121263-19-2.mol |
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CALPHOSTIN C Property |
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solubility : |
DMF: 1 mg/mL
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CALPHOSTIN C Chemical Properties,Usage,Production |
Chemical Properties
Dark red solid |
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Usage
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. |
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Usage
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines. |
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Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM). |
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CALPHOSTIN C Preparation Products And Raw materials |
Raw materials
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Preparation Products
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CALPHOSTIN C Suppliers Global( 37)Suppliers |
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CALPHOSTIN C
CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES
2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER
BioChemical
Cell Biology
Cell Signaling and Neuroscience
121263-19-2
UCN-1028C
Kinase/Phosphatase Biology
Serine/Threonine Kinase Inhibitors
Protein Kinase C (PKC)
CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES
C44H38O14
(R)-Calphostin C
1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione
4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione
Calphostin C,98%
Calphostin CUCN-1028C
(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester
Calphostin C(UCN 1028C, PKF 115584)
C,CalphostinCfroMCladosporiuMcladosporioide
UCN 1028 C, PKF 115-384
Cladochrome E
PKF 115-584
He Ding C Carver
Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer
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