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| Products Intro: |
Product Name:Calphostin C, 98%
CAS:121263-19-2
Purity:98% Package:0.1MG |
| Company Name: | Meryer (Shanghai) Chemical Technology Co., Ltd. |
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Product Name:Calphostin C
CAS:121263-19-2
Purity:98% Remarks:32818 |
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Product Name:Calphostin C;(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetraMethoxy-3,10-dioxo-1-perylenyl]-1-Methylethylcarbonicacid4-hydroxyphenylester
CAS:121263-19-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g |
| Company Name: | Chembest Research Laboratories Limited |
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Product Name:Calphostin C(UCN 1028C, PKF 115584)
CAS:121263-19-2
Remarks:C10021 |
| Company Name: | Wuhan Chemwish Technology Co., Ltd |
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| Products Intro: |
Product Name:CalphostinC
CAS:121263-19-2
Purity:98% Package:1g;5g;25g;50g;100g;500g |
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| | CALPHOSTIN C Basic information |
| Product Name: | CALPHOSTIN C | | Synonyms: | CALPHOSTIN C;CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES;2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER;UCN-1028C;CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES;(R)-Calphostin C;1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione;4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione | | CAS: | 121263-19-2 | | MF: | C44H38O14 | | MW: | 790.76 | | EINECS: | | | Product Categories: | | | Mol File: | 121263-19-2.mol |  |
| | CALPHOSTIN C Chemical Properties |
| storage temp. | −20°C
| | solubility | DMF: 1 mg/mL
| | form | powder
| | color | red to brown
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| | CALPHOSTIN C Usage And Synthesis |
| Chemical Properties | Dark red solid | | Usage | Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. | | Usage | Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines. | | Biological Activity | Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM). |
| | CALPHOSTIN C Preparation Products And Raw materials |
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