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| CAS No. | 208255-80-5 |
| Chemical Name: | DAPT |
| Synonyms: | GSI-IX;SC-201315;DAPT (GSI-IX);EZSolution DAPT;SC-201315 DAPT;Synonyms GSI-IX;DAPT (enzyme inhibitor);γ-Secretase Inhibitor IX;DAPT
DAPT (enzyme inhibitor);(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester |
| CBNumber: | CB3503380 |
| Molecular Formula: | C23H26F2N2O4 |
| Formula Weight: | 432.464 |
| MOL File: | 208255-80-5.mol |
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| DAPT Property |
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| solubility : |
DMSO: ~18 mg/mL
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DAPT Chemical Properties,Usage,Production |
Usage
DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells |
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Biological Activity
Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. |
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| DAPT Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| DAPT Suppliers Global( 56)Suppliers |
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208255-80-5
LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
C23H26F2N2O4
γ-Secretase Inhibitor IX
Angiogenesis and Metastasis
Protease inhibitor
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester
SC-201315
(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester
DAPT (enzyme inhibitor)
GSI-IX
DAPT (GSI-IX)
tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate
Inhibitor
(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
GSI-IX
SC-201315 DAPT
Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-,1,1-diMethylethyl ester, (2S)-
(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester DAPT (enzyme inhibitor)
DAPT
DAPT (enzyme inhibitor)
Synonyms GSI-IX
EZSolution DAPT
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