1-Methyl-2-pyrrolidinone

1-Methyl-2-pyrrolidinone Property

mp : −24 °C(lit.) bp : 202 °C(lit.) density : 1.028 g/mL at 25 °C(lit.) vapor density : 3.4 (vs air) vapor pressure : 0.29 mm Hg ( 20 °C) refractive index : n20/D 1.479 Fp : 187 °F storage temp. : 2-8°C color : ≤20(APHA) Water Solubility : >=10 g/100 mL at 20 ºC Sensitive : Hygroscopic Merck : 14,6117 BRN : 106420 Stability:: Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases. CAS DataBase Reference: 872-50-4(CAS DataBase Reference) NIST Chemistry Reference: 2-Pyrrolidinone, 1-methyl-(872-50-4) EPA Substance Registry System: 2-Pyrrolidinone, 1-methyl-(872-50-4)

Safety

Hazard Codes : T,Xi Risk Statements : 45-65-36/38-36/37/38-61-10-46 Safety Statements : 41-45-53-62-26 WGK Germany : 1 RTECS : UY5790000 F : 3-8-10 TSCA : Y Hazardous Substances Data: 872-50-4(Hazardous Substances Data)

1-Methyl-2-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties colourless or light yellow liquid with an amine odour Usage high purity grade for ICP-MS detection Usage It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts. General Description A clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199°F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Air & Water Reactions Soluble in water. Reactivity Profile This amine is a very mild chemical base. 1-Methyl-2-pyrrolidinone does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Health Hazard Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation. Fire Hazard Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire.

1-Methyl-2-pyrrolidinone Preparation Products And Raw materials

Raw materials Acetone METHYLAMINE Butyramide gamma-Butyrolactone

Preparation Products 4-(Trifluoromethyl)nicotinic acid 1-BENZOFURAN-5-CARBONITRILE Trimethylsilyl cyanide 3,5-DIMETHOXYPHENYLACETIC ACID 2-(DIPHENYLPHOSPHINO)ETHYLTRIETHOXYSILANE 4-Aminobutyric acid 3-AMINO-2-FLUORO-4-PICOLINE 5-(Trifluoromethyl)pyridine-2-carboxylic acid 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine C-(1H-INDOL-5-YL)-METHYLAMINE Vat Orange 9 ethyl 2-(4-chloroquinazolin-7-yloxy)acetate THIOPHENE-2-THIOCARBOXAMIDE 5-Cyanoindole 3-Amino-6-chloropyridine-2-carboxylic acid 3-Amino-2-pyridinecarbonitrile 2-Furonitrile 1-(3-AMINOPROPYL)-2-PYRROLIDINONE 2-Chloro-6-trifluoromethylnicotinic acid 6-chloro-1H-indazol-3-amine 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE 2-Trifluoromethyl-5-bromopyridine 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE 2-Trifluoromethyl-6-pyridinecarboxylic acid 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE 4-(PYRROLIDIN-1-YLMETHYL)BENZENEBORONIC ACID, PINACOL ESTER 97%1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]PYRROLIDINE

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