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Cyclosporin H

CAS番号.83602-39-5
化学名:
别名:
英語化学名:Cyclosporin H
英語别名:Sandoz 37-839;CYCLOSPORIN H;Cyclosporine IMpurity-H;5-(N-Methyl-D-valine)cyclosporin A;Cyclosporin H, froM MicroMonospora;5-(N-Methyl-D-valine)cyclosporine A;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl]
CBNumber:CB8279114
分子式:C62H111N11O12
分子量:1202.61
MOL File:83602-39-5.mol
Cyclosporin H 物理性質
融点 : 148-151°C
貯蔵温度 : -20°C Freezer
安全性情報

Cyclosporin H 化学特性,用途語,生産方法

化学的特性
White Powder
使用
An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
使用
Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
使用
Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclosporin H is the most extensively investigated of the minor cyclosporin analogues . It is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
Cyclosporin H 上流と下流の製品情報
原材料
準備製品
Cyclosporin H 生産企業      Global( 58)Suppliers     
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Fujian Kerui Pharmaceutical Co., Ltd. 159601039190591-83309157fjkerui@gmail.comCHINA 22 62
Shanghai Tauto Biotech Co., Ltd 0086-21-513205880086-21-51320502export2@tautobiotech.comCHINA 4011 66
Chongqing Chemieliva Pharmaceutical Co., Ltd. +86 (23) 6777-0219+86 (23) 6777-0220jessica.hu@chemieliva.comCHINA 50 60
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BOC Sciences 1-631-504-60931-631-614-7828sales@bocsci.comUSA 9972 65
 
83602-39-5(Cyclosporin H) キーワード:
(3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]シクロ(L-Leu-L-Ala-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-) (3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]-シクロ(L-Leu-L-Thr-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-) (3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]-シクロ[L-Leu-L-Abu-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Lys-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-] (3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]-シクロ(L-Leu-L-Nva-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-) (3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]シクロ(L-Leu-L-Val-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-) シクロ[L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-N-メチル-2-[(2R,4E)-2-メチル-4-ヘキセニル]-L-Gly-L-Abu-N-メチル-Gly-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-] 4-ヒドロキシ安息香酸メチル シクロスポリン p-トルエンスルホニルメチル イソシアニド ベンジルスルホニルフルオリド (3R,4R)-3-ヒドロキシ-N-メチル-5-[(E)-1-プロペニル]-シクロ(L-Leu-L-Abu-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-) シクロペンタン ヘキサメチルりん酸トリアミド 2-[[[[(4-メトキシ-6-メチル-1,3,5-トリアジン-2-イル)(メチル)アミノ]カルボニル]アミノ]スルホニル]安息香酸メチル アクリル酸メチル サリチル酸メチル メタノール クレソキシムメチル
83602-39-5 CYCLOSPORIN H Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl] 5-(N-Methyl-D-valine)cyclosporin A Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl] Sandoz 37-839 Cyclosporine IMpurity-H 5-(N-Methyl-D-valine)cyclosporine A Cyclosporin H, froM MicroMonospora
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