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トリコスタチンA

CAS番号.58880-19-6
化学名:トリコスタチンA
别名:トリコスタチンA;(2E,4E,6R)-4,6-ジメチル-7-オキソ-7-[4-(ジメチルアミノ)フェニル]-2,4-ヘプタジエンヒドロキシム酸;(2E,4E,6R)-4,6-ジメチル-7-[4-(ジメチルアミノ)フェニル]-7-オキソ-2,4-ヘプタジエンヒドロキシム酸;(2E,4E,6R)-7-[4-(ジメチルアミノ)フェニル]-N-ヒドロキシ-4,6-ジメチル-7-オキソ-2,4-ヘプタジエナミド
英語化学名:TRICHOSTATIN A
英語别名:TSA;A 300I;TRICHOSTATIN A;(R)-Trichostatin A;Trichostatin A (TSA);Trichostatin A, Streptomyces sp.;TRICHOSTATIN A FROM STREPTOMYCES SP;Trichostatin A, Ready Made Solution;TRICHOSTATIN A, STREPTOMYCES SPECIES;Trichostatin A from Streptomyces platensis
CBNumber:CB8257301
分子式:C17H22N2O3
分子量:302.37
MOL File:58880-19-6.mol
トリコスタチンA 物理性質
融点 : 140-143℃
比重(密度) : 1.139
屈折率 : 136 ° (C=0.3, MeOH)
貯蔵温度 : −20°C
solubility : ethanol: 1 mg/mL
Merck : 9649
安全性情報
主な危険性 : Xn,Xi
Rフレーズ : 20/21/22-36/37/38-43
Sフレーズ : 26-36
WGK Germany : 3
RTECS 番号: MI5215000

トリコスタチンA 化学特性,用途語,生産方法

化学的特性
Solid
使用
Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
使用
Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
使用
Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumor activity
生物活性
Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
トリコスタチンA 上流と下流の製品情報
原材料
準備製品
トリコスタチンA 生産企業      Global( 86)Suppliers     
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58880-19-6(トリコスタチンA) キーワード:
MG-132 LY294002 トリコスタチンA (2E,4E)-N-ヒドロキシ-2,4-ヘキサジエンアミド
58880-19-6 (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide TSA TRICHOSTATIN A TRICHOSTATIN A, STREPTOMYCES SPECIES Trichostatin A, Streptomyces sp. 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- TRICHOSTATIN A FROM STREPTOMYCES SP Trichostatin A from Streptomyces platensis [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid (2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (R)-Trichostatin A Trichostatin A (TSA) A 300I (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide Trichostatin A, Ready Made Solution トリコスタチンA (2E,4E,6R)-4,6-ジメチル-7-オキソ-7-[4-(ジメチルアミノ)フェニル]-2,4-ヘプタジエンヒドロキシム酸 (2E,4E,6R)-4,6-ジメチル-7-[4-(ジメチルアミノ)フェニル]-7-オキソ-2,4-ヘプタジエンヒドロキシム酸 (2E,4E,6R)-7-[4-(ジメチルアミノ)フェニル]-N-ヒドロキシ-4,6-ジメチル-7-オキソ-2,4-ヘプタジエナミド 生化学 試験研究用抗腫瘍剤 阻害剤
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