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17,23β-エポキシベラトラマン-3β-オール

CAS番号.4449-51-8
化学名:17,23β-エポキシベラトラマン-3β-オール
别名:シクロパミン;17,23β-エポキシベラトラマン-3β-オール;11-デオキソジェルビン;17β,23β-エポキシベラトラマン-3β-オール
英語化学名:CYCLOPAMINE
英語别名:alkaloidv;CYCLOPAMINE;11-DEOXYJERVINE;11-DEOXOJERVINE;11-deoxo-jervin;CYCLOPAMINE(RG);17,23β-Epoxyveratraman-3β-ol;17β,23β-Epoxyveratraman-3β-ol;CyclopaMine (11-deoxojervine);CyclopaMine, froM VeratruM californiciM
CBNumber:CB7677669
分子式:C27H41NO2
分子量:411.62
MOL File:4449-51-8.mol
17,23β-エポキシベラトラマン-3β-オール 物理性質
融点 : 236-238°C
貯蔵温度 : 2-8°C
solubility : DMSO: soluble
外見 : solid
安定性：: Store in Freezer at - 20°C
安全性情報
主な危険性 : Xi
Sフレーズ : 22-24/25
WGK Germany : 3
RTECS 番号: GY0750000
有毒物質データの: 4449-51-8(Hazardous Substances Data)

17,23β-エポキシベラトラマン-3β-オール 化学特性,用途語,生産方法

化学的特性
White Crystalline Solid
使用
Has antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 Solubility: 1mg dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.) Solubility: 4mg dissolves in 1ml 95% Ethanol
使用
Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.
生物活性
Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anti-cancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment.
17,23β-エポキシベラトラマン-3β-オール 上流と下流の製品情報
原材料
準備製品
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4449-51-8(17,23β-エポキシベラトラマン-3β-オール) キーワード:
17,23β-エポキシベラトラマン-3β-オール
4449-51-8 CYCLOPAMINE 11-DEOXOJERVINE 11-DEOXYJERVINE (2'R,3S,3'R,3'AS,6'S,6AS,6BS,7'AR,11AS,11BR)-1,2,3,3'A,4,4',5',6,6',6A,6B,7,7',7'A,8,11,11A,11B-OCTADECAHYDRO-3',6',10,11B-TETRAMETHYLSPIRO[9H-BENZO[A]FLUORENE-9,2'(3'H)-FURO[3,2-B]PYRIDIN]-3-OL 11-deoxo-jervin 17,23-epoxy-,(3-beta,23-beta)-veratraman-3-o alkaloidv (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol 17,23β-Epoxyveratraman-3β-ol 17β,23β-Epoxyveratraman-3β-ol (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol Cyclopamine hydrate,11-deoxojervine hydrate CyclopaMine (11-deoxojervine) (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- CYCLOPAMINE(RG) CyclopaMine, froM VeratruM californiciM Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol シクロパミン 17,23β-エポキシベラトラマン-3β-オール 11-デオキソジェルビン 17β,23β-エポキシベラトラマン-3β-オール
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