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| CAS番号. | 304909-07-7 |
| 化学名: | |
| 别名: | |
| 英語化学名: | SANT-1 |
| 英語别名: | SANT-1;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine;N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE;1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- |
| CBNumber: | CB2141123 |
| 分子式: | C23H27N5 |
| 分子量: | 373.49 |
| MOL File: | 304909-07-7.mol |
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SANT-1 化学特性,用途語,生産方法 |
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使用
A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G pro
tein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). |
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生物活性
Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells). |
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| SANT-1 上流と下流の製品情報 |
原材料
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準備製品
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| SANT-1 生産企業 Global( 25)Suppliers |
| 名前 | 電話番号 | ファックス番号 | 電子メール | 国籍 | 製品カタログ | 優位度 |
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J & K SCIENTIFIC LTD.
| -- | -- | jkinfo@jkchemical.com;market3@jkchemical.com | CHINA |
96847
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76
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3B Pharmachem (Wuhan) International Co.,Ltd.
| 86-21-50328103 * 801、802、803、804 Mobile:18930552037 | 86-21-50328109 | 67055399@qq.com | CHINA |
15983
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69
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Chemsky（shanghai）International Co.,Ltd.
| 021-50135380 | | shchemsky@sina.com | CHINA |
32553
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50
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Jinan Trio PharmaTech Co., Ltd.
| +86 (531) 88811793；+86 (531) 88811783;+(0)18854807083; | +86 (531) 55696010 QQ981200479 | sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market) | CHINA |
1779
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62
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ShangHai Biochempartner Co.,Ltd
| +86 13818785766，400-021-9906 | | gaoqing@biochempartner.com | CHINA |
1167
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62
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
| 021-20337333/400-620-6333 | 021-50323701 | sale@aladdin-e.com | CHINA |
24330
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65
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Shanghai TaoSu Biochemical Technology Co., Ltd.
| 021-33632979 | 021-33632979 | info@tsbiochem.com | CHINA |
3112
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58
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AdooQ Bioscience CHINA
| 400-025-6535 | 025-68650336 | info@adooq.cn | CHINA |
2299
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60
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Hubei Jusheng Technology Co.,Ltd
| North:027-59599241,18871490274,QQ:1400878000 South:027-59531287,15727001360,QQ:1400878866 | ℡ 027-83861211 | 469501031@qq.com | CHINA |
10512
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58
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Shanghai Lollane Biological Technology Co.,Ltd.
| +86-21-61128122 | +86-21-61128122 | sales@lollanechem.com | CHINA |
991
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55
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