SB203580

CAS番号.	152121-47-6
化学名:	SB203580
别名:	SB203580
英語化学名:	SB 203580
英語别名:	PB 203580;SB 203580;RWJ 64809;SB 203580 HYDROCHLORIDE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine
CBNumber:	CB1680333
分子式:	C21H16FN3OS
分子量:	377.43
MOL File:	152121-47-6.mol

SB203580 物理性質

融点 :

144-146

貯蔵温度 :

−20°C

solubility :

DMSO: 50 mg/mL

外見 :

solid

color :

white to off-white

安定性：:

-200C

CAS データベース:

152121-47-6(CAS DataBase Reference)

安全性情報

主な危険性 :

Rフレーズ :

22-41

Sフレーズ :

26-39

WGK Germany :

SB203580 化学特性,用途語,生産方法

化学的特性
White to Off-White Solid

使用
A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase

使用
A p38 MAPK inhibitor with an IC50 range of 0.3-0.5 μM and blocks PKB phosphorylation with an IC50 range of 3-5 μM.

生物活性
Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

SB203580 上流と下流の製品情報

原材料

準備製品

SB203580 生産企業 Global( 82)Suppliers

名前	電話番号	ファックス番号	電子メール	国籍	製品カタログ	優位度
Shanghaizehan biopharma technology co., Ltd.	0086-021-61350663 13052117465	0086-021-61350662	sales@zehanbiopharma.com	CHINA	498	55
Beijing Dependence Chemistry Co., Ltd.	+86 (10) 60279497	+86 (10) 60279497	sales@dcechem.com	CHINA	20	58
Shanghai Boyle Chemical Co., Ltd.	Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)	86-21-57758967	sales@boylechem.com	CHINA	5604	55
J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
3B Pharmachem (Wuhan) International Co.,Ltd.	86-21-50328103 * 801、802、803、804 Mobile:18930552037	86-21-50328109	67055399@qq.com	CHINA	15983	69
Chembest Research Laboratories Limited	+86(0)21-20908456	+86(0)21-58180499	sales@biochembest.com	CHINA	6000	61
Ascent Scientific	4401179829988	4402030 700 369	customerservice@ascentscientific.co.uk	UNITED KINGDOM	282	60
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	+86 (21) 5772-1279，+86 (21) 6775-2378	+86 (21) 6775-2378，QQ：14057904	sales@shydchem.com.cn, sales@shydtec.com	CHINA	925	56
Chemfun Medical Technology(Shanghai) Co., Ltd.	021-67220633 & 021-37212706	+86-21-67220638	chemfun@chemfun.net	CHINA	21915	59
VDM Biochemicals	0330-2528181	0330-2528171	sales@vdmbio.com	USA	511	64

152121-47-6(SB203580) キーワード:

2,6-ジヒドロ-1,2-ジアザアセアントリレン-6-オン PD98059溶液 LY294002 SB203580 2,4-ジフェニル-1H-イミダゾール

152121-47-6 SB 203580 SB 203580 HYDROCHLORIDE 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL 4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine PB 203580 Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- 4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole RWJ 64809 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB 203580 SB 203580 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB203580