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(-)PPP

CAS No.477-47-4
Chemical Name:(-)PPP
Synonyms:(-)PPP;AXL1717;AXL 1717;AXL-1717;NSC 36407;PICROPODOPHYLLIN;Pictopodophyllotoxin;IGF-1R Inhibitor, PPP;POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE);(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CBNumber:CB8708520
Molecular Formula:C22H22O8
Formula Weight:0
MOL File:Mol file
(-)PPP Property
mp : 225-227℃
density : 1.370
storage temp. : 2-8°C
solubility : H2O: soluble
Safety
Hazard Codes : Xi,T
Risk Statements : 36/37/38-68-25-21
Safety Statements : 26-36-45-36/37
RIDADR : UN 3462 6.1/PG 2
WGK Germany : 3
RTECS : LV2510000

(-)PPP Chemical Properties,Usage,Production

Usage
Insulin growth factor 1 receptor inhibitor, antineoplastic
Biological Activity
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .
(-)PPP Preparation Products And Raw materials
Raw materials
Preparation Products
(-)PPP Suppliers      Global( 24)Suppliers     
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3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
VDM Biochemicals 0330-25281810330-2528171sales@vdmbio.comUSA 511 64
BEST-REAGENT 028-85973071 028-85973075028-85973075service@best-reagent.comCHINA 9961 57
Dalian Meilun Biotech Co., Ltd. 0411-66771943；0411-667719420411-66771945sales@meilune.comCHINA 5010 58
SembCorp Shenzhenshibai a Biotechnology Co., Ltd 13412890622,0755-26737815/26017435-6080755-26737815/26017435-600biokang@126.com，xuy1101@126.comCHINA 21 55
Chengdu Biopurify Phytochemicals Ltd. 86-28-82633397+86-28-82633165sales@biopurify.comCHINA 1953 60
Shanghai Haoyuan Chemexpress Co., Ltd 86-21-5899859086-21-53700326, 86-21-58998590sales@chemexpress.cnCHINA 10011 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333021-50323701sale@aladdin-e.comCHINA 24330 65
MedChemexpress LLC 609-228-6898609-228-5909sales@medchemexpress.cnUSA 4935 58
AdooQ BioScience, LLC +1 (866) 930-6790+1 (866) 333-9607info@adooq.comUSA 2786 58
 
477-47-4((-)PPP)Related Search:
ETHYL 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONATE 7-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID 6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBALDEHYDE Masoprocol 1,2,3,4-TETRAHYDRO-2-NAPHTHOIC ACID 7-HYDROXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID (-)PPP 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Anwuligan 6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID 2-NAPHTHALENECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-6-HYDROXY- 2-Methyl-3-[(3,4-methylenedioxy)phenyl]propionic acid, 98%
PICROPODOPHYLLIN (-)PPP POLY(2,5-BIS(3-SULFONATOPROPOXY)-1,4-PHENYLENE, DISODIUM SALT-ALT-1,4-PHENYLENE) 477-47-4 NSC 36407, Picropodophyllin, PPP, (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one IGF-1R Inhibitor, PPP (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one NSC 36407 Pictopodophyllotoxin Insulin-like Growth Factor-1 Receptor Inhibitor Picropodophyllin AXL 1717 AXL1717 AXL-1717 (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
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