(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester

CAS No.	461054-93-3
Chemical Name:	(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
Synonyms:	Ko 143;12aS)-;4-dioxo-;Ko143 ,99%;6]pyrido[3;Pyrazino[1';Ko143 hydrate;4-b]indole-3-propanoicacid;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1;tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7, 12,12a-octahydropyrazino[1
CBNumber:	CB81562442
Molecular Formula:	C26H35N3O5
Formula Weight:	469.57
MOL File:	461054-93-3.mol

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester Property

mp :

147 ºC

density :

1.24

storage temp. :

Desiccate at -20°C

Safety

Hazard Codes :

Risk Statements :

36/37/38

Safety Statements :

26-36

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester Chemical Properties,Usage,Production

Usage
A potent BCRP (breast cancer resistance protein) inhibitor

Biological Activity
Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance.

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester Suppliers Global( 25)Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
3B Pharmachem (Wuhan) International Co.,Ltd.	86-21-50328103 * 801、802、803、804 Mobile:18930552037	86-21-50328109	67055399@qq.com	CHINA	15983	69
Chembest Research Laboratories Limited	+86(0)21-20908456	+86(0)21-58180499	sales@biochembest.com	CHINA	6000	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	001-617-206-9595	sales@chemreagents.com	USA	9949	62
Lanzhou Boc Chemical Co., Ltd	86-021-34975602/34975603 021-34970311	+86-21-34975602-805	sales@bocchem.com	CHINA	949	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380		shchemsky@sina.com	CHINA	298	58
Chemsky (shanghai) International Co.,Ltd	021-50135380		shchemsky@sina.com	CHINA	15730	60
ShangHai Biochempartner Co.,Ltd	+86 13818785766，400-021-9906		gaoqing@biochempartner.com	CHINA	1167	62
Shanghai LiuShi Pharmaceutical Technology Co., Ltd.	021-60135539	021-38721356	shlschemical@hotmail.com	CHINA	9967	55
Shanghai Haoyuan Chemexpress Co., Ltd	86-21-58998590	86-21-53700326, 86-21-58998590	sales@chemexpress.cn	CHINA	10011	61

461054-93-3((3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester)Related Search:

TERT-BUTYL PROPIONATE 3-Indolepropionic acid CYCLO(-GLY-GLU) CYCLO(-GLY-TRP) CYCLO(-ALA-GLU) 3-PIPERAZIN-2-YL-PROPIONIC ACID METHYL ESTER 3-PIPERAZIN-2-YL-PROPIONIC ACID (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester Methoxy p-Anisidine 4-Methoxybenzylchloride Anisic aldehyde (Trifluoromethoxy)benzene 4-Methoxyphenylacetone 4-Methoxyphenylacetic acid Anisole 3-(METHOXYMETHOXY)BENZALDEHYDE

461054-93-3 Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143) Ko 143 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester C26H35N3O5 C26H36N3O5 Ko143 ,99% 12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1 12aS)- 4-b]indole-3-propanoicacid 4-dioxo- 6]pyrido[3 Pyrazino[1' Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Ko143 hydrate tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7, 12,12a-octahydropyrazino[1 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester hydrate