Terfenadine

CAS No.	50679-08-8
Chemical Name:	Terfenadine
Synonyms:	Cyater;Terdin;terfen;Terfex;Aldaban;mdl9918;rmi9918;seldane;Teldane;MDL-9918
CBNumber:	CB7695393
Molecular Formula:	C32H41NO2
Formula Weight:	471.67
MOL File:	50679-08-8.mol

Terfenadine Property

mp :	145-152 °C

storage temp. :

2-8°C

Water Solubility :

0.001 g/100 mL (30 ºC)

CAS DataBase Reference:

50679-08-8(CAS DataBase Reference)

NIST Chemistry Reference:

Seldane(50679-08-8)

Safety

Safety Statements :

24/25

WGK Germany :

RTECS :

TM4969000

Hazardous Substances Data:

50679-08-8(Hazardous Substances Data)

Terfenadine Chemical Properties,Usage,Production

Chemical Properties
White Solid

Usage
Nonsedating-type histamine H1-receptor antagonist. Antihistaminic

Usage
H1 antihistamine

Biological Activity
Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .

Terfenadine Preparation Products And Raw materials

Raw materials
Isobutylbenzene Potassium hydroxide Potassium iodide Acetone alpha,alpha-Diphenyl-4-piperidinomethanol POTASSIUM BICARBONATE Toluene 4-Chlorobutyryl chloride Sodium borohydride 4-Piperidinemethanol Aluminium chloride Difenidol hydrochloride Hydrochloric acid Potassium borohydride Methanol Isopropanol

Preparation Products

Terfenadine Suppliers Global( 66)Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)	+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)	sh@meryer.com	CHINA	40407	62
3B Pharmachem (Wuhan) International Co.,Ltd.	86-21-50328103 * 801、802、803、804 Mobile:18930552037	86-21-50328109	67055399@qq.com	CHINA	15983	69
Ascent Scientific	4401179829988	4402030 700 369	customerservice@ascentscientific.co.uk	UNITED KINGDOM	282	60
LGM Pharma	1-(800)-881-8210	615-250-9817	inquiries@lgmpharma.com	USA	1972	70
Nanjing Chemlin Chemical Co., Ltd	025-83697070; 010-68547217	+86-25-83453306	sales@chemlin.com.cn	CHINA	20120	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380		shchemsky@sina.com	CHINA	32553	50
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	86-21-63290778 86-21-63218885	sj_scrc@sinopharm.com	CHINA	10006	79
Thermo Fisher Scientific	800-810-5118	+86-10-84193589	cnchemical@thermofisher.com	CHINA	17599	75
Beijing HuaMeiHuLiBiological Chemical	010-56205725;010-86181995	010-65763397	waley188@sohu.com	CHINA	12409	58

50679-08-8(Terfenadine)Related Search:

Terfenadine-(butanol-1,2,2-d3) FEXOFENADINE, METHYL ESTER FEXOFENADINE HYDROCHLORIDE Fexofenadine hydrochloride TERFENADINE ALCOHOL METABOLITE FEXOFENADINE-D6 S-FEXOFENADINE R-FEXOFENADINE Terfenadine Dichlorodiphenylsilane Diphenylmethane tert-Butylchlorodiphenylsilane 1,3-Diphenyl-2-thiourea Phenylacetic acid Diphenylsilane Diphenylphosphine Chlorodiphenylphosphine PHENYL VALERATE

Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical ALPHA-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL 50679-08-8 TERFENADINE Enzymes, Inhibitors, and Substrates Substrates Xenobiotics and Drug Metabolism 1-(4-tert-butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol 1-(4-tert-Butylphenyl)-4-(4-[hydroxy(diphenyl)methyl]-1-piperidinyl)-1-butanol 1-(p-tert-butylphenyl)-4-(4’-(alpha-hydroxydiphenylmethyl)-1’-piperidyl)-butan 1-Piperidinebutanol, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- 1-piperidinebutanol,alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmeth Aldaban Allerplus alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebu alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebuta alpha-(p-tert-butylphenyl)-4-(alpha-hydroxy-alpha-phenylbenzyl)-1-piperidinebu alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Cyater mdl9918 MDL-9918 Nebralin RMI 9918 rmi9918 rmi-9918 seldane Teldane Teldanex Terdin terfen terfenadina(inn-spanish) terfenadinum(inn-latin) Terfex Ternadin treludan Triludan 1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperid-1-yl)butan-1-ol Terfenadine (Patent No Supply) 3-[2-Thienyl]-L-Alanine99.5% C32H41NO2 α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol TERFENADINE(SUBJECTTOPATENTFREE) 1-Piperidinebutanol, a-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- (9CI) a-(p-tert-Butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol dl-Terfenadine Histadin NSC 665802 Racemic terfenadine A3，5-Diethoxy Acetopheone a-[4-(1,1-Dmethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals A1lerplus