Chinese  Japanese  Germany

5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE

CAS No.4311-88-0
Chemical Name:5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE
Synonyms:Nec 1;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;IFLAB-BB F0911-6127;5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN;MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan;Methylthiohydantoin-DL-tryptophan, MTH-DL-tryptophan;5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE;5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone;4-IMidazolidinone, 5-(1H-indol-3-ylMethyl)-3-Methyl-2-thioxo-
CBNumber:CB6776886
Molecular Formula:C13H13N3OS
Formula Weight:259.33
MOL File:4311-88-0.mol
5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE Property
mp : 151℃
density : 1.40±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. : −20°C
solubility : DMSO: >10 mg/mL
form : solid
Safety
WGK Germany : 3

5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE Chemical Properties,Usage,Production

Usage
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Usage
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
Biological Activity
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE Preparation Products And Raw materials
Raw materials
Preparation Products
5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE Suppliers      Global( 48)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885021-65675885info@efebio.comCHINA 2042 58
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
VDM Biochemicals 0330-25281810330-2528171sales@vdmbio.comUSA 511 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.comCHINA 32553 50
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811793；+86 (531) 88811783;+(0)18854807083;+86 (531) 55696010 QQ981200479sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market)CHINA 1779 62
Syntechem Co.,Ltd info@syntechem.com QQ 421151915E-Mail Inquiryinfo@syntechem.comCHINA 13109 57
China Langchem Inc. 0086-21-58956006,021-58950017;021-387018070086-21-58956100sales@langchem.comCHINA 11187 57
BOC Sciences 1-631-504-60931-631-614-7828sales@bocsci.comUSA 9972 65
Lanzhou Tech Biochemical Co., Ltd. 18993966060 QQ25029165300943-8288977sales@techbiochem.comCHINA 992 61
 
4311-88-0(5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE)Related Search:
3-METHYLADENINE Bortezomib Y27632 (hydrochloride) Saracatinib Erlotinib hydrochloride Z-VAD-FMK [2-(1H-INDOL-3-YL)-ETHYL]-THIOUREA MTH-DL-ALANINE PHENYLTHIOHYDANTOIN-TRYPTOPHAN 5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE PTH-TRYPTOPHAN
IFLAB-BB F0911-6127 Cell Biology Cell Signaling and Neuroscience Apoptosis and Cell Cycle Apoptosis Inhibitors BioChemical 5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE 4311-88-0 5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN NECROSTATIN-1 MTH-DL-TRYPTOPHAN MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan Miscellaneous Signaling 5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Apoptosis Inhibitors 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, 5-(Indol-3-ylmethyl)-3-methyl-2-thio-hydantoin, MTH-DL-Tryptophan Nec 1 Methylthiohydantoin-DL-tryptophan, MTH-DL-tryptophan 4-IMidazolidinone, 5-(1H-indol-3-ylMethyl)-3-Methyl-2-thioxo- Inhibitor 5-((1H-indol-3-yl)Methyl)-3-Methyl-2-thioxoiMidazolidin-4-one 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Necrostatin 1 Necrostatin 1 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Copyright 2016 © ChemicalBook. All rights reserved