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CAS No. | 193551-21-2 |
Chemical Name: | SB 239063 |
Synonyms: | SB 239063;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-4-[4-(4-FLUOROPHENYL)-5-(2-METHOXY-4-PYRIMIDINYL)-1H-IMIDAZOL-1-YL]CYCLOHEXANOL;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIDIMIDIN-4-YL)IMIDAZOLE;Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans- |
CBNumber: | CB6100319 |
Molecular Formula: | C20H21FN4O2 |
Formula Weight: | 368.4 |
MOL File: | 193551-21-2.mol |
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SB 239063 Property |
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solubility : |
DMSO: 11 mg/mL
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SB 239063 Chemical Properties,Usage,Production |
Usage
SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. A protein kinase inhibitor |
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Biological Activity
Potent and selective p38 MAP kinase inhibitor (IC 50 = 44 nM for p38a). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-i midazol-4-yl]pyridine and 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H- imidazol-4-yl]pyridine hydrochloride
). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo . |
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SB 239063 Preparation Products And Raw materials |
Raw materials
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Preparation Products
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SB 239063 Suppliers Global( 24)Suppliers |
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