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TACROLIMUS

CAS No.109581-93-3
Chemical Name:TACROLIMUS
Synonyms:FK-506;Tacarolimus;tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);tsukubaenolidehydrate;Tacrolimus monohydrate;TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE;,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-;18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*
CBNumber:CB4772400
Molecular Formula:C44H69NO12
Formula Weight:822.04
MOL File:109581-93-3.mol
TACROLIMUS Property
storage temp. : −20°C
Safety
Hazard Codes : T
Risk Statements : 25
Safety Statements : 45
RIDADR : UN 2811 6.1/PG 3
RTECS : KD4201200

TACROLIMUS Chemical Properties,Usage,Production

Usage
immune suppressant, antifungal
Biological Activity
Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .
TACROLIMUS Preparation Products And Raw materials
Raw materials
Preparation Products
TACROLIMUS Suppliers      Global( 62)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comCHINA 40407 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
TCI (Shanghai) Development Co., Ltd. ----info@chemicalbook.comCHINA 22159 81
Energy Chemical 021-58432009 / 400-005-6266021-58436166-800info@energy-chemical.comCHINA 44198 61
Ascent Scientific 44011798299884402030 700 369customerservice@ascentscientific.co.ukUNITED KINGDOM 282 60
LGM Pharma 1-(800)-881-8210615-250-9817inquiries@lgmpharma.comUSA 1972 70
Sinopharm Chemical Reagent Co,Ltd. 86-21-6321012386-21-63290778 86-21-63218885sj_scrc@sinopharm.comCHINA 10006 79
Shanghai Hope Chem Co., Ltd.， 021-61723543QQ: 3251508270 ;sales@hope-chem.comCHINA 788 55
 
109581-93-3(TACROLIMUS)Related Search:
TACROLIMUS Ethyl1-butyl-2-piperidinecarbxylate Ascomycin N-LAUROYLSARCOSINE H-HOMOPRO-OME HCL 1-(2-methylpiperidin-1-yl)acetone Tacrolimus N-LAUROYL-L-ALANINE
FK-506 BioChemical Cell Biology 109581-93-3 Cell Signaling and Neuroscience Kinase/Phosphatase Biology Protein Phosphatase 2B (Calcineurin/PP2B) Serine/Threonine Phosphatase Inhibitors ,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))- 18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r* 3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12, tacrolimushydrate tsukubaenolidehydrate FK-506 MONOHYDRATE Tacarolimus 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-te 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE C44H69NO12H2O Tacrolimus monohydrate Signalling (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone Tacrolimus (150 mg) (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-
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