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| CAS No. | 28380-24-7 |
| Chemical Name: | NIGERICIN SODIUM SALT |
| Synonyms: | x-464;Helix c;NIGERICIN;HELIXIN C;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;ANTIBIOTIC K178 |
| CBNumber: | CB4331016 |
| Molecular Formula: | C40H67NaO11 |
| Formula Weight: | 746.94 |
| MOL File: | 28380-24-7.mol |
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| NIGERICIN SODIUM SALT Property |
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| solubility : |
chloroform: 10 mg/mL, clear, colorless
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NIGERICIN SODIUM SALT Chemical Properties,Usage,Production |
Usage
Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication. |
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Usage
Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication. |
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| NIGERICIN SODIUM SALT Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| NIGERICIN SODIUM SALT Suppliers Global( 33)Suppliers |
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| 28380-24-7(NIGERICIN SODIUM SALT)Related Search: |
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3,6,9,12-tetraoxahexadecan-1-ol
11-HENEICOSANOL
1,3,3-TRIMETHOXYBUTANE
TRICOSANOIC ACID
CAPRIC ACID SODIUM SALT
pentadecane-1,2-diol
SODIUM ISOBUTYRATE
NIGERICIN SODIUM SALT
3-HYDROXYHEXADECANOIC ACID
1,20-EICOSANEDIOL
11-HYDROXY LAURIC ACID
N-NONACOSANE
1-TERT-BUTOXY-2-PROPANOL
1,2,9-NONANETRIOL
n-Octacosane
1-(2-METHOXYETHOXY)-2-METHYL-2-PROPANOL
2,5-DIETHYLTETRAHYDROFURAN
1,16-HEXADECANEDIOL
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AZALOMYCIN M
HELIXIN C
ANTIBIOTIC K178
ANTIBIOTIC K178 SODIUM SALT
ANTIBIOTIC X-464
BioChemical
Antibiotics A to Z
Antibiotics N-S
Antibiotics
28380-24-7
x-464
NIGERICIN
NIGERICIN NA
NIGERICIN, NA SALT
NIGERICIN, SODIUM SALT, STREPTOMYCES HYGROSCOPICUS
POLYETHERIN A
nigericin sodium from streptomyces*hygroscopicus
nigericin sodium salt from streptomyces hygroscopicus
NIGERICIN APPOX. 95%
Nigericin from Streptomyces hygroscopicus
Antibiotic K178 sodium salt, Azalomycin M
nigericin sodium
(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid
28643-80-3 (Sodium salt)
Aids003767
Aids-003767
Helix c
C40H68O11
antibiotic
Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464
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