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CAS No. | 78919-13-8 |
Chemical Name: | ILOPROST |
Synonyms: | zk36374;Ilomedin;Endoprost;CILOPROST;Iloprost Na;1h)-pentalenylidene)-;(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2);pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(;6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID;5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid |
CBNumber: | CB3775439 |
Molecular Formula: | C22H32O4 |
Formula Weight: | 360.49 |
MOL File: | 78919-13-8.mol |
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ILOPROST Property |
storage temp. : |
Desiccate at -20°C |
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ILOPROST Chemical Properties,Usage,Production |
Chemical Properties
Colourless Oil |
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Usage
A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. |
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Biological Activity
Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively). |
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ILOPROST Preparation Products And Raw materials |
Raw materials
Iloprost
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Preparation Products
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ILOPROST Suppliers Global( 35)Suppliers |
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(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)
1h)-pentalenylidene)-
pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(
zk36374
6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID
78919-13-8
CILOPROST
5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid
Endoprost
Ilomedin
(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoicacid
Chiral Reagents
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
(1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-Methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane
(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid
Iloprost Na
Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-,(5E)-
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