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CAS No. | 123318-82-1 |
Chemical Name: | Clofarabine |
Synonyms: | CAFDA;200mg;Clola;Clolar;Evoltra;Clofarex;CLOFARABINE;CLORFARABINE;Clofarabine, Free Base;CLOFARABINE(FORR&DONLY) |
CBNumber: | CB2277491 |
Molecular Formula: | C10H11ClFN5O3 |
Formula Weight: | 303.68 |
MOL File: | 123318-82-1.mol |
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Clofarabine Property |
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storage temp. : |
Desiccate at +4°C |
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Clofarabine Chemical Properties,Usage,Production |
Chemical Properties
White Solid |
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Usage
ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic |
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Biological Activity
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. |
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Clofarabine Preparation Products And Raw materials |
Raw materials
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Preparation Products
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Clofarabine Suppliers Global( 181)Suppliers |
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123318-82-1(Clofarabine)Related Search: |
Capecitabine
Gemcitabine hydrochloride
9-(2,3-DIDEOXY-2-FLUORO-ALPHA-D-THREOPENTOFURANOSYL)-ADENINE
2-chloro-2',3'-dideoxyadenosine
2-chloro-9-methyl-9H-purine
Cladribine
Clofarabine
AMINO ACIDS
Tris(hydroxymethyl)nitromethane
Fludarabine phosphate
Fluorine
Chenodeoxycholic acid
Fludarabine
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
Glycine
ALTRENOGEST
D-METHAMPHETAMINE
Difluorochloromethane
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123318-82-1
2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
CLOFARABINE
CAFDA
2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
Clolar
Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE
C10H11ClFN5O3
Clola
2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
CLOFARABINE(FORR&DONLY)
CLOFARABINE, 5-(6-AMINO-2-CHLORO-PURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL
CLORFARABINE
(2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE (CLOFARABINE)
2-Chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purin-6-amine
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Bases & Related Reagents
Nucleotides
6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine
Pharmaceutical intermediate
2-Chloro-6-aMino-purine-2'-fluoro-2'- deoxy arabin
200mg
(2R,3R,4S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyMethyl)oxolan-3-ol
Clofarabine, Free Base
Clofarex
Evoltra
CLOLAR
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-2-arabino-fluoro-2-deoxyadenosine
Antineoplastic
Anti-cancer&immunity
6-AMino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
6-AMino-2-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
23318-82-1
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