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Clofarabine

CAS No.123318-82-1
Chemical Name:Clofarabine
Synonyms:CAFDA;200mg; Clola;Clolar;Evoltra;Clofarex;CLOFARABINE;CLORFARABINE;Clofarabine, Free Base;CLOFARABINE(FORR&DONLY)
CBNumber:CB2277491
Molecular Formula:C10H11ClFN5O3
Formula Weight:303.68
MOL File:123318-82-1.mol
Clofarabine Property
mp : 228-2310C
storage temp. : Desiccate at +4°C
CAS DataBase Reference: 123318-82-1(CAS DataBase Reference)
Safety
Hazard Codes : T
Risk Statements : 25
Safety Statements : 45

Clofarabine Chemical Properties,Usage,Production

Chemical Properties
White Solid
Usage
ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic
Biological Activity
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Clofarabine Preparation Products And Raw materials
Raw materials
Preparation Products
Clofarabine Suppliers      Global( 181)Suppliers     
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Nanjing Baifuli Technology Co., Ltd. 86-025-58740604, 5835685886-025-58356858sales@unisyn.cnCHINA 930 58
Shanghai Micro-Mega Industry Co., Ltd. +86 (21) 34628682 18918069061+86 (21) 54285906weij@micro-megaindustry.com; 2880705930@qq.comCHINA 66 55
Chongqing Chemieliva Pharmaceutical Co., Ltd. +86 (23) 6777-0219+86 (23) 6777-0220jessica.hu@chemieliva.comCHINA 50 60
Wuhu Nuowei chemistry Co., Ltd. 0553-2911116 180553116000553-2911116salesnuowei@163.comCHINA 1020 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comCHINA 40407 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
Chembest Research Laboratories Limited +86(0)21-20908456+86(0)21-58180499sales@biochembest.comCHINA 6000 61
TCI (Shanghai) Development Co., Ltd. ----info@chemicalbook.comCHINA 22159 81
 
123318-82-1(Clofarabine)Related Search:
Capecitabine Gemcitabine hydrochloride 9-(2,3-DIDEOXY-2-FLUORO-ALPHA-D-THREOPENTOFURANOSYL)-ADENINE 2-chloro-2',3'-dideoxyadenosine 2-chloro-9-methyl-9H-purine Cladribine Clofarabine AMINO ACIDS Tris(hydroxymethyl)nitromethane Fludarabine phosphate Fluorine Chenodeoxycholic acid Fludarabine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Glycine ALTRENOGEST D-METHAMPHETAMINE Difluorochloromethane
123318-82-1 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol CLOFARABINE CAFDA 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine Clolar Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE C10H11ClFN5O3 Clola 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)- CLOFARABINE(FORR&DONLY) CLOFARABINE, 5-(6-AMINO-2-CHLORO-PURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL CLORFARABINE (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)- 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE (CLOFARABINE) 2-Chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purin-6-amine Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Bases & Related Reagents Nucleotides 6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine Pharmaceutical intermediate 2-Chloro-6-aMino-purine-2'-fluoro-2'- deoxy arabin 200mg (2R,3R,4S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyMethyl)oxolan-3-ol Clofarabine, Free Base Clofarex Evoltra CLOLAR (2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-2-arabino-fluoro-2-deoxyadenosine Antineoplastic Anti-cancer&immunity 6-AMino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine 6-AMino-2-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside 5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol 23318-82-1
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