Chinese  Japanese  Germany

ChemicalBook >> CAS DataBase List >> KENPAULLONE

KENPAULLONE

CAS No.142273-20-9
Chemical Name:KENPAULLONE
Synonyms:Kenpaullon;NSC-664704;KENPAULLONE;9-BroMopaullone;9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;9-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]BENZAZEPIN-6(5H)-ONE;8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704;Kenpaullone 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
CBNumber:CB1449240
Molecular Formula:C16H11BrN2O
Formula Weight:327.18
MOL File:142273-20-9.mol
KENPAULLONE Property
mp : >300°C (dec.)
storage temp. : 2-8°C
solubility : DMSO: 18 mg/mL, clear, yellow
color : yellow
CAS DataBase Reference: 142273-20-9(CAS DataBase Reference)
Safety
Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 26-36
WGK Germany : 3

KENPAULLONE Chemical Properties,Usage,Production

Chemical Properties
Tan Solid
Usage
The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3?inhibitor (IC50=23nM).
Biological Activity
Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
KENPAULLONE Preparation Products And Raw materials
Raw materials
Preparation Products
KENPAULLONE Suppliers      Global( 56)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.comCHINA 32553 50
China DongFan Chemical Co.,LTD 86-0571-8515118286-0571-85151182sales@dongfan-chem.comCHINA 5718 66
ChemCell Biomedicine Co.,Ltd. 18818868158 QQ:5836791160086-0757-85406358chemcell@hotmail.comCHINA 134 52
BOC Sciences 1-631-504-60931-631-614-7828sales@bocsci.comUSA 9972 65
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539021-38721356shlschemical@hotmail.comCHINA 9967 55
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587+86-21-61294319sales@topbiochem.comCHINA 9691 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988+86-27-87599188sales@ncebiomed.comCHINA 1503 55
 
142273-20-9(KENPAULLONE)Related Search:
5-BROMOINDOLE-3-ACETAMIDE 1H-INDOLE, 5-BROMO-2-PHENYL- (2-PHENYL-1H-INDOL-3-YL)-ACETALDEHYDE 2-(2-AMINOPHENYL)INDOLE KENPAULLONE
142273-20-9 Cell Biology Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators Apoptosis and Cell Cycle BioChemical 9-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]BENZAZEPIN-6(5H)-ONE 8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE KENPAULLONE NSC-664704 C16H11BrN2O All Inhibitors Inhibitors 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704 Protein Kinase 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 9-BroMopaullone Kenpaullon Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Kenpaullone 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one 142273-29-9
Copyright 2016 © ChemicalBook. All rights reserved