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INDIRUBIN-3'-MONOXIME

CAS No.160807-49-8
Chemical Name:INDIRUBIN-3'-MONOXIME
Synonyms:Indirubin-3'INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3’-MONOOXIME;3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE
CBNumber:CB1325944
Molecular Formula:C16H11N3O2
Formula Weight:277.28
MOL File:160807-49-8.mol
INDIRUBIN-3'-MONOXIME Property
mp : 247-249°C
density : 1.50
storage temp. : Store at RT
solubility : DMSO: >10 mg/mL
form : solid
Stability:: Light Sensitive
Safety
WGK Germany : 3

INDIRUBIN-3'-MONOXIME Chemical Properties,Usage,Production

Chemical Properties
Dark Red Solid
Usage
A potent inhibitor of GSK-3? (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).
Biological Activity
Protein kinase inhibitor: inhibits cyclin-dependent kinases (IC 50 = 0.18-3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
INDIRUBIN-3'-MONOXIME Preparation Products And Raw materials
Raw materials
Preparation Products
INDIRUBIN-3'-MONOXIME Suppliers      Global( 33)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418001-617-206-9595sales@chemreagents.comUSA 9949 62
VDM Biochemicals 0330-25281810330-2528171sales@vdmbio.comUSA 511 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.comCHINA 32553 50
BOC Sciences 1-631-504-60931-631-614-7828sales@bocsci.comUSA 9972 65
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539021-38721356shlschemical@hotmail.comCHINA 9967 55
Shanghai Famo Bio-chemical Technology Company Ltd. +86 (21) 6816-0314+86 (21) 5816-6562sales@famobiotech.comCHINA 238 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333021-50323701sale@aladdin-e.comCHINA 24330 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969020-39119999isunpharm@qq.com, isunpharm@hotmail.comCHINA 4836 55
 
160807-49-8(INDIRUBIN-3'-MONOXIME)Related Search:
Indirubin 1-METHYL-BIO (2'Z,3'E)-6-BROMOINDIRUBIN-3'-OXIME INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID INDIRUBIN-3'-MONOXIME, 5-IODO- (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME INDIRUBIN-3'-MONOXIME
3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE Apoptosis and Cell Cycle BioChemical Cell Biology Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators 160807-49-8 INDIRUBIN-3'-MONOXIME INDIRUBIN-3'-OXIME Indirubine-3'-oxime Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes Inhibitors Protein Kinase INDIRUBIN-3’-MONOOXIME Intracellular Signaling Indirubin-3'
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