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AC480 (BMS-599626)

CAS No.714971-09-2
Chemical Name:AC480 (BMS-599626)
Synonyms:BMS 599626 ;AC480 (BMS-599626);(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,;[(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrrolo;(S)-morpholin-3-ylmethyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-ylcarbamate;(S)-MORPHOLIN-3-YLMETHYL 4-(1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YLAMINO)-5-METHYLPYRROLO[2,1-F][1,2,4]-TRIAZIN-6-YLCARBAMATE;(3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate;N-[4-[[1-[(3-Fluorophenyl)Methyl]-1H-indazol-5-yl]aMino]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbaMic Acid (3S)-3-MorpholinylMethyl Ester;CARBAMIC ACID, [4-[[1-[(3-FLUOROPHENYL)METHYL]-1H-INDAZOL-5-YL]AMINO]-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]-, (3S)-3-MORPHOLINYLMETHYL ESTER;Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester (9CI)
CBNumber:CB12464670
Molecular Formula:C27H27FN8O3
Formula Weight:530.561
MOL File:714971-09-2.mol
AC480 (BMS-599626) Property
Safety

AC480 (BMS-599626) Chemical Properties,Usage,Production

Usage
BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.
Usage
It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhibiting tumors in which receptor coexpression and heterodimerization play a major role in driving tumor growth.
AC480 (BMS-599626) Preparation Products And Raw materials
Raw materials
Preparation Products
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714971-09-2(AC480 (BMS-599626))Related Search:
XL413 (BMS-863233) Tamoxifen citrate Toremifene citrate Entinostat CUDC-101 Olaparib 5-Amino-1-(3-fluorobenzyl)indazole AC480 (BMS-599626) 3(R)-HYDROXYMETHYLMORPHOLINE PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE
(S)-MORPHOLIN-3-YLMETHYL 4-(1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YLAMINO)-5-METHYLPYRROLO[2,1-F][1,2,4]-TRIAZIN-6-YLCARBAMATE 714971-09-2 CARBAMIC ACID, [4-[[1-[(3-FLUOROPHENYL)METHYL]-1H-INDAZOL-5-YL]AMINO]-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]-, (3S)-3-MORPHOLINYLMETHYL ESTER C27H27FN8O3 BMS 599626 Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester (9CI) 8173837-23-1 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals N-[4-[[1-[(3-Fluorophenyl)Methyl]-1H-indazol-5-yl]aMino]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbaMic Acid (3S)-3-MorpholinylMethyl Ester [(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrrolo C26H25FN8O3 (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1, AC480 (BMS-599626) (S)-morpholin-3-ylmethyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-ylcarbamate (3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
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