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CAS号: | 144689-78-1 |
英文名称: | Olmesartan |
英文同义词: | MEDOXOMIL;Olmesartan;n-Butyl OlMesartan MedoxoMil;2-butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;2-Butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID (5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYL ESTER;1H-IMIDAZOLE-5-CARBOXYLIC ACID, 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-, (5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYL ESTER |
中文名称: | 奥美沙坦酯 |
中文同义词: | 奥美沙坦酯;2,3-二羟基-2-丁烯基-4-(1-羟基-1-甲基乙基)-2-丁基-1-[4-(2-1H-四唑-5-苯基)苄基]咪唑-5-羧酸酯环-2,3-碳酸酯 |
CBNumber: | CB5350012 |
分子式: | C24H26N6O3 |
分子量: | 446.5 |
MOL File: | 144689-78-1.mol |
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奥美沙坦酯 性质、用途与生产工艺 |
沙坦类抗高血压药
奥美沙坦酯是一种沙坦类抗高血压药,1991年由日本三共株式会社研制成功,在众多国家获得专利保护,专利号为:EP0503785,专利优先国为日本;该产品合成工艺在中国申请了相关专利,CN1045770及CN1381453。它克服了血管紧张素转换酶抑制剂(ACEI)的缺点并保存其优点,其作用类似但不引起ACEI类药物导致的干咳、皮疹和血管神经性水肿等作用,不良反应较小,病人耐受性好,在轻中度高血压治疗中疗效良好,在临床上比较受欢迎。
奥美沙坦酯具有强效的降压作用,口服后在小肠壁完全去酯转化成活性代谢产物奥美沙坦(Olmesartan),奥美沙坦是一种选择性非肽类血管紧张素II受体拮抗剂,通过选择性阻断血管紧张素Ⅱ与血管平滑肌AT1受体的结合而阻断血管紧张素Ⅱ的收缩血管作用,每天5mg、20mg和40mg的用药剂量,可分别降低坐位收缩压12.4mmHg、15.1mmHg和17.6mmHg;降低坐位舒张压9.8mmHg、12.2mmHg和13.1mmHg。在小鼠和大鼠急性毒性实验中,单次口服给药最大剂量达2000mg/kg时,仍没有致死结果出现。狗的最小致死量大于1500mg/kg。未见致癌性、致畸性、致突变性、生殖毒性和遗传毒性。
常见的沙坦类抗高血压药物:缬沙坦、厄贝沙坦、替米沙坦,坎地沙坦酯、依普沙坦、他索沙坦、奥美沙坦酯。
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奥美沙坦酯 生产厂家 全球有 61家供应商
奥美沙坦酯国内生产厂家
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144689-78-1, 奥美沙坦酯 相关搜索: |
聚丁烯
乙二醇单丁醚
三苯基乙基溴化膦
二乙二醇丁醚
噻嗪酮
丙烯酸正丁酯
奥美沙坦酯
过氧化乙酸叔丁酯
美沙酮
羟基乙叉二膦酸
马来酸
苄基三乙基氯化铵
乙酸丁酯
一水氢溴酸右旋美沙芬
氰氟草酯
马来酸酐
6-乙基-5-氟嘧啶-4(3H)-酮
2,3-二羟基-2-丁烯基-4-(1-羟基-1-甲基乙基)-2-丙基-1-[4-(2-1H-四唑-5-苯基)苄基]咪唑-5-羧酸酯环-2,3-碳酸酯
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Cnbio
医药原料
原料药
中间体
C30H32N6O6
奥美沙坦酯
2,3-二羟基-2-丁烯基-4-(1-羟基-1-甲基乙基)-2-丁基-1-[4-(2-1H-四唑-5-苯基)苄基]咪唑-5-羧酸酯环-2,3-碳酸酯
144689-78-1
n-Butyl OlMesartan MedoxoMil
Olmesartan
2-Butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID (5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYL ESTER
4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
1H-IMIDAZOLE-5-CARBOXYLIC ACID, 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-, (5-METHYL-2-OXO-1,3-DIOXOL-4-YL)METHYL ESTER
2-butyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
MEDOXOMIL
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