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| CAS号: | 192927-92-7 |
| 英文名称: | LY310762 |
| 英文同义词: | LY 310762 HCl;LY-310,762 HYDROCHLORIDE;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride;2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride |
| 中文名称: | LY310762 |
| 中文同义词: | 1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐 |
| CBNumber: | CB0488147 |
| 分子式: | C24H27O2N2FHCl |
| 分子量: | 0 |
| MOL File: | 192927-92-7.mol |
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| LY310762化学性质 |
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| 溶解度 : |
DMSO: 10 mg/mL with heating, soluble
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LY310762 性质、用途与生产工艺 |
生物活性
LY310762是一种5-HT1D受体拮抗剂，Ki为249 nM，对5-HT1B受体具有较低的亲和力。
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体外研究
LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40%. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan.
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体内研究
Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control.
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| LY310762 上下游产品信息 |
上游原料
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下游产品
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| 192927-92-7, LY310762 相关搜索: |
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4-(4-氟苯甲酰基)哌啶盐酸盐
LY310762
匹美汀
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神经信号
C24H27FN2O2HCl
C24H27O2N2FHCl
C24H28ClFN2O2
1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐
192927-92-7
1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride
2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride
1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride
LY 310762 HCl
3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
LY-310,762 HYDROCHLORIDE
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