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CAS番号. | 58970-76-6 |
化学名: | [(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH |
别名: | N-[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル]-L-Leu-OH;N-[(2S,3R)-3-アミノ-2-ヒドロキシ-1-オキソ-4-フェニルブチル]-L-ロイシン;ベスタチン;ウベニメックス;(-)-N-[(2S,3R)-3-アミノ-2-ヒドロキシ-1-オキソ-4-フェニルブチル]-L-ロイシン;N-[(2S,3R)-2-ヒドロキシ-3-アミノ-4-フェニルブチリル]ロイシン;(2S)-2-[[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル]アミノ]-4-メチル吉草酸;ウベニメクス;N-[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブタノイル]-L-ロイシン;N-[(2S,3R)-2-ヒドロキシ-3-アミノ-4-フェニルブチリル]-L-ロイシン;[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH;(-)-ベスタチン;N-((2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル)-L-ロイシン |
英語化学名: | Ubenimex |
英語别名: | nk421;BENIMEX;BESTATIN;UBENIMEX;NSC 265489;UbeniMex(Bestatin);Bestatin, UbeniMex;UbenaMix, Inobestin, NK 421;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU-OH |
CBNumber: | CB9324019 |
分子式: | C16H24N2O4 |
分子量: | 308.37 |
MOL File: | 58970-76-6.mol |
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[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH 物理性質 |
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安全性情報 |
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[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH MSDS Ubenimex
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[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH 化学特性,用途語,生産方法 |
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使用
Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration |
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使用
Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials. |
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使用
Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials. |
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生物活性
Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation. |
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[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH 上流と下流の製品情報 |
原材料
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準備製品
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[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH 生産企業 Global( 157)Suppliers |
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58970-76-6
3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine
n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin
nk421
UBENIMEX
N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE
N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE
[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE
[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU
[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU-OH
[(2S, 3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE
BESTATIN
[S-(R*,S*)]-N-(3-amino-2-hydroxy-4-phenylbutyroyl)-L-leucine
BENIMEX
L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
L-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]- (9CI)
NSC 265489
[S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbuty1)-L-leucine
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine,97%
UbeniMex(Bestatin)
N-[(2S,3R)-3-AMino-2-hydroxy-4-phenylbutyryl]-L-leucine, 97% 500MG
Bestatin, UbeniMex
(2R)-2-[(2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido]-4-Methylpentanoic acid
(S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid
UbenaMix, Inobestin, NK 421
L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-
N-[(2S,3R)-3-AMino-2-hydroxy-4-phenylbutyryl]-L-leucine 97%
N-[(2S,3R)-3-AMino-2-hydroxy-4-phenylbutyryl]-L-leucine|(-)-N-[3(R)-AMino-2(S)-hydroxy-4-phenylbutyryl]-L-leucine
[S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine
N-[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル]-L-Leu-OH
N-[(2S,3R)-3-アミノ-2-ヒドロキシ-1-オキソ-4-フェニルブチル]-L-ロイシン
ベスタチン
ウベニメックス
(-)-N-[(2S,3R)-3-アミノ-2-ヒドロキシ-1-オキソ-4-フェニルブチル]-L-ロイシン
N-[(2S,3R)-2-ヒドロキシ-3-アミノ-4-フェニルブチリル]ロイシン
(2S)-2-[[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル]アミノ]-4-メチル吉草酸
ウベニメクス
N-[(2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブタノイル]-L-ロイシン
N-[(2S,3R)-2-ヒドロキシ-3-アミノ-4-フェニルブチリル]-L-ロイシン
[(3R)-3-アミノ-3-ベンジル-L-Lac-]Leu-OH
(-)-ベスタチン
N-((2S,3R)-3-アミノ-2-ヒドロキシ-4-フェニルブチリル)-L-ロイシン
酵素阻害剤
抗腫瘍薬
免疫療法薬
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