(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Produkt Beschreibung

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt:: 216 °C (dec.)(lit.) storage temp. : 2-8°C solubility : H2O: 10 mg/mL, clear, red-orange Merck : 13,3473 CAS Datenbank: 25316-40-9(CAS DataBase Reference) EPA chemische Informationen: 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)

Sicherheit

Kennzeichnung gefährlicher: T,T+,Xi R-Sätze:: 45-22-40-26/27/28-36/38 S-Sätze:: 53-45-36/37/39-22-7/9 WGK Germany : 3 RTECS-Nr.: QI9295900 F : 10-21

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften Orange-Red Crystalline Solid Verwenden Used as an antineoplastic Verwenden Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent. Verwenden Antibacterial;DNA intercalant Verwenden Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. Verwenden Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. Allgemeine Beschreibung Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9. Air & Water Reaktionen Water soluble. Reaktivität anzeigen Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Brandgefahr Doxorubicin hydrochloride is probably combustible. R-Sätze Betriebsanweisung: R45:Kann Krebs erzeugen. R22:Gesundheitsschädlich beim Verschlucken. R40:Verdacht auf krebserzeugende Wirkung. R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut. S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen. S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen). S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen. S22:Staub nicht einatmen. S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren. Biologische Aktivit?t Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien Daunorubicin

Downstream Produkte

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 247)Lieferanten      CANADA 1 CHINA 165 Europe 5 FRANCE 1 GERMANY 8 INDIA 2 JAPAN 5 SWITZERLAND 4 UNITED KINGDOM 12 USA 44 Global 247

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