| Company Name: | Chembest Research Laboratories Limited Gold |
| Tel: | +86(0)21-20908456 |
| Email: | sales@biochembest.com |
| Products Intro: |
Product Name:Epothilone B(Patupilone)
CAS:152044-54-7
Remarks:C13626 |
| Company Name: | Hubei Widely Chemical Technology Co., Ltd. Gold |
| Tel: | 027-83778895 18827677254 18627097818 |
| Email: | harry.t@foxmail.com 18827677254@163.com |
| Products Intro: |
Product Name:Epothilone B
CAS:152044-54-7
Purity:99% Package:50g |
| Company Name: | Wuhan Bo-Sen Biological Technology Co., Ltd Gold |
| Tel: | 027-51335350 15107175693 |
| Email: | bosenyuan@foxmail.com |
| Products Intro: |
Product Name:Epothilone B;Patupilone;4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;EPO 906A;
CAS:152044-54-7
Purity:99.0% Package:5G |
| Company Name: | Shanghai Boyle Chemical Co., Ltd. |
| Tel: | Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market) |
| Email: | sales@boylechem.com |
| Products Intro: |
Product Name:Patupilone
CAS:152044-54-7
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| | Patupilone Basic information |
| Product Name: | Patupilone | | Synonyms: | 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;EPO 906A;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;Epothilone B;Patupilone;()-Epothilone B,EPO906, EpoB, Patupilone;Epothilone B(EPO906);Epothilone B HOUSE STANDARD | | CAS: | 152044-54-7 | | MF: | C27H41NO6S | | MW: | 507.68 | | EINECS: | | | Product Categories: | Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds | | Mol File: | 152044-54-7.mol |  |
| | Patupilone Chemical Properties |
| mp | 95-97°C | | density | 1.136 | | storage temp. | Store at -20°C |
| | Patupilone Usage And Synthesis |
| Chemical Properties | White Powder | | Usage | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
| | Usage | Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. | | Biological Activity | Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo . |
| | Patupilone Preparation Products And Raw materials |
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