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イロプロスト

CAS番号.78919-13-8
化学名:イロプロスト
别名:イロプロスト
英語化学名:ILOPROST
英語别名:zk36374;Ilomedin;Endoprost;CILOPROST;Iloprost Na;1h)-pentalenylidene)-;(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2);pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(;6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID;5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid
CBNumber:CB3775439
分子式:C22H32O4
分子量:360.49
MOL File:78919-13-8.mol
イロプロスト 物理性質
貯蔵温度 : Desiccate at -20°C
安全性情報

イロプロスト 化学特性,用途語,生産方法

化学的特性
Colourless Oil
使用
A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
生物活性
Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).
イロプロスト 上流と下流の製品情報
原材料
準備製品
イロプロスト 生産企業      Global( 35)Suppliers     
名前電話番号ファックス番号電子メール国籍製品カタログ優位度
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
Chemvon Biotechnology Co., Ltd +86-21-50790412+86-21-50790419marketing@chemvon.comCHINA 259 57
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Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706+86-21-67220638chemfun@chemfun.netCHINA 21915 59
LGM Pharma 1-(800)-881-8210615-250-9817inquiries@lgmpharma.comUSA 1972 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.comCHINA 32553 50
China DongFan Chemical Co.,LTD 86-0571-8515118286-0571-85151182sales@dongfan-chem.comCHINA 5718 66
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（CSR Factory）China Skyrun Industrial CO.,ltd info@chinaskyrun.commanager@chinaskyrun.comsales@chinaskyrun.comCHINA 12226 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611+86 21 50676805contact@trustwe.comCHINA 9988 58
 
78919-13-8(イロプロスト) キーワード:
78919-13-8 (16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2) 1h)-pentalenylidene)- pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2( zk36374 6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID CILOPROST 5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid Endoprost Ilomedin (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoicacid (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-Methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid Iloprost Na Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-,(5E)- イロプロスト
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