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| CAS番号. | 160807-49-8 |
| 化学名: | |
| 别名: | |
| 英語化学名: | INDIRUBIN-3'-MONOXIME |
| 英語别名: | Indirubin-3'INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3’-MONOOXIME;3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE |
| CBNumber: | CB1325944 |
| 分子式: | C16H11N3O2 |
| 分子量: | 277.28 |
| MOL File: | 160807-49-8.mol |
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| INDIRUBIN-3'-MONOXIME 物理性質 |
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| solubility : |
DMSO: >10 mg/mL
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INDIRUBIN-3'-MONOXIME 化学特性,用途語,生産方法 |
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使用
A potent inhibitor of GSK-3? (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM). |
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生物活性
Protein kinase inhibitor: inhibits cyclin-dependent kinases (IC 50 = 0.18-3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation. |
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| INDIRUBIN-3'-MONOXIME 上流と下流の製品情報 |
原材料
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準備製品
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| INDIRUBIN-3'-MONOXIME 生産企業 Global( 33)Suppliers |
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