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Quinupristin-dalfopristin

CAS番号.126602-89-9
化学名:
别名:
英語化学名:Quinupristin-dalfopristin
英語别名:SYNERCID;Quinupristin-dalfopristin;Quinupristin-Dalfopristin Mesylate coMplex;Synercid coMplex, Dalfopristin-Quinupristin coMplex
CBNumber:CB11252296
分子式:C53H67N9O10S.C34H50N4O9S
分子量:1713.09
MOL File:126602-89-9.mol
Quinupristin-dalfopristin 物理性質
安全性情報

Quinupristin-dalfopristin 化学特性,用途語,生産方法

使用
Quinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as SynercidTM. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.
使用
Quinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as Synercid. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.
Quinupristin-dalfopristin 上流と下流の製品情報
原材料
準備製品
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126602-89-9(Quinupristin-dalfopristin) キーワード:
(R)-(+)-1-エチル-2-ピロリジンカルボン酸エチル N-[(3-ヒドロキシ-2-ピリジル)カルボニル]シクロ[L-Thr*-D-Abu-L-Pro-N-メチル-L-Phe-4-オキソ-L-Pip-L-フェニルGly-] (R)-(+)-2-(メトキシメチル)-1-ピロリジンカルボキシアルデヒド 1-ブチル-4-ピペリジノン イソブチル スルフィド 3-ヒドロキシピコリノイル-シクロ[L-Thr*-D-Abu-L-Pro-4-メチルアミノ-N-メチル-L-Phe-4-オキソ-L-Hpr-L-フェニルGly-] ダルホプリスチン
126602-89-9 Quinupristin-dalfopristin SYNERCID Quinupristin-Dalfopristin Mesylate coMplex Synercid coMplex, Dalfopristin-Quinupristin coMplex
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