Pyrimethamine

Pyrimethamine Property

mp : 233-234°C storage temp. : 0-6°C Water Solubility : <0.01 g/100 mL at 21 ºC Stability:: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents. CAS DataBase Reference: 58-14-0(CAS DataBase Reference) NIST Chemistry Reference: Pyrimethamine(58-14-0) EPA Substance Registry System: 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0)

Safety

Hazard Codes : Xn Risk Statements : 22 RIDADR : 3249 WGK Germany : 3 RTECS : UV8140000 HazardClass : 6.1(b) PackingGroup : III

Pyrimethamine Chemical Properties,Usage,Production

Chemical Properties White Solid Usage Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial Usage For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine General Description Odorless white crystalline powder. Tasteless. An antimalarial drug. Air & Water Reactions Insoluble in water. Reactivity Profile Pyrimethamine is sensitive to exposure to light . Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Fire Hazard Flash point data for Pyrimethamine are not available; however, Pyrimethamine is probably combustible. Biological Activity Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).

Pyrimethamine Preparation Products And Raw materials

Raw materials Ethyl propionate 4-Chlorobenzyl cyanide

Preparation Products

Pyrimethamine Suppliers      Global( 156)Suppliers      CANADA 1 CHINA 105 Europe 4 FRANCE 1 GERMANY 3 INDIA 2 JAPAN 4 Slovakia 1 SWITZERLAND 1 UNITED KINGDOM 6 USA 28 Global 156

Supplier Tel Fax Email Country ProdList Advantage J & K SCIENTIFIC LTD. -- -- jkinfo@jkchemical.com;market3@jkchemical.com CHINA 96847 76 3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037 86-21-50328109 67055399@qq.com CHINA 15983 69 TAIYUAN RHF CO.,LTD. +86 351 7031519 +86 351 7031519 sales@RHFChem.com CHINA 2366 56 TCI (Shanghai) Development Co., Ltd. -- -- info@chemicalbook.com CHINA 22159 81 BeiJing Hwrk Chemicals Limted 4006990298 010-57411839 020-31335234 021-51691807 010-87653215 0757-86311057 021-55236763 sales@hwrkchemical.com CHINA 12649 55 Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 0086-571-85864795 sales@capotchem.com CHINA 18282 66 BePharm Ltd. (Click here for a quote) 40068-59117; 86-21-51816456-8021/8022/8023 +86-21-51816740 (China Mainland); +86-21-51816457 (Others) product@bepharm.com CHINA 24999 61 Jia Xing Isenchem Co.,Ltd 0573-85280080 18267390595 0573-85285100 isenchem@163.com,QQ:1404038297 CHINA 9788 66 Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 001-617-206-9595 sales@chemreagents.com USA 9949 62 Shanghai Longsheng chemical Co.,Ltd. 0086-21-58099637,58099652,58099650,58099609 To 8017,8068; 13585536065 0086-21-33191781 sales@shlschem.com; bin.wu@shlschem.com；xianjun.hong@shlschem.com CHINA 9850 59