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| CAS No. | 1037184-44-3 |
| Chemical Name: | YK-4-279 |
| Synonyms: | YK-4-279;4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one;4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one YK-4-279 |
| CBNumber: | CB72518568 |
| Molecular Formula: | C17H13Cl2NO4 |
| Formula Weight: | 0 |
| MOL File: | Mol file |
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| YK-4-279 Property |
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| storage temp. : |
Store at -20° C. |
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YK-4-279 Chemical Properties,Usage,Production |
Chemical Properties
A crystalline solid |
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Usage
An oncogenic fusion protein found in Ewing's sarcoma, a family of undifferentiated tumors which occur throughout the body. The binding of ES-FLI1 to RNA helicase A (RHA) promotes its oncogenic function. Inhibits protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing's sarcoma tumor cell lines with IC50 values ranging from 0.5 to 2 μM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing's sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks. |
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| YK-4-279 Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| YK-4-279 Suppliers Global( 23)Suppliers |
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