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Aminopterin

CAS No.54-62-6
Chemical Name:Aminopterin
Synonyms:AGPA;apga;nsc739;apga[qr];ent-26079;pteramina;nsc739[qr];Aminoperin;Minopterin;AMINOPTERIN
CBNumber:CB6418254
Molecular Formula:C19H20N8O5
Formula Weight:440.41
MOL File:54-62-6.mol
Aminopterin Property
mp : 228-235 °C (dec.)
alpha : 18 º (c=1% in 0.1N NaOH)
storage temp. : 2-8°C
solubility : 2 M NaOH: 50 mg/mL
form : powder
color : yellow
Merck : 13,471
CAS DataBase Reference: 54-62-6(CAS DataBase Reference)
EPA Substance Registry System: L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl) methyl]amino]benzoyl]-(54-62-6)
Safety
Hazard Codes : T+
Risk Statements : 61-28-63-26/27/28
Safety Statements : 53-28-36/37-45-36/37/39-22
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS : MA1050000
F : 8-10-23
HazardClass : 6.1(a)
PackingGroup : I
Hazardous Substances Data: 54-62-6(Hazardous Substances Data)

Aminopterin Chemical Properties,Usage,Production

Chemical Properties
Dark Yellow Solid
Usage
A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Usage
antineoplastic, antirheumatic, folic acid antagonist
General Description
Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
Health Hazard
An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.
Aminopterin Preparation Products And Raw materials
Raw materials
Preparation Products
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54-62-6(Aminopterin)Related Search:
7-HYDROXY METHOTREXATE METHOTREXATE-[3',5',7-3H(N)] DISODIUM SALT [3',5',7-3H]METHOTREXATE, SODIUM SALT METHOTREXATE SODIUM SALT, [3',5',7'-3H] Methotrexate Methyl 2,4,7-Triamino-6-phenylpteridine 6-Aminocaproic acid 4-Acetamidophenol (6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE Glycine D-(+)-NEOPTERIN TEA-LAUROYL GLUTAMATE L-Glutamic acid EC 2.6.1.2 Methylparaben Glutamic acid Benzoyl peroxide
4-amino-4-deoxypteroylglutamate 4-amino-folicaci 4-aminofolicacid[qr] 4-amino-pga[qr] 4-aminopteroylglutamicacid[qr] 4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci AGPA ai3-26079[qr] aminopteridine aminopterinum aminopterinum[qr] a-ninopterin apga apga[qr] ent-26079 ent-26079[qr] kyselina4-aminolistova kyselina4-aminolistova(czech)[qr] kyselina4-aminopteroylglutamova kyselina4-aminopteroylglutamova(czech)[qr] kyselinan-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-l(+)-glutamova kyselinan-(p-((2,4-diamino-6-pteridinylmethyl)benzoyl)-l(+)-glutamova(czech) l-glutamicacid,n-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-[qr] n-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-l-glutamicacid n-(4-((2,4-diamino-6-pteridyl)-methyl)amino)benzoyl)-l-glutamicacid[qr] n-(p-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-glutamicacil-[qr] n-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-l-glutamicaci nsc739 nsc739[qr] pteramina pteramina(czech)[qr] Substrate Analogs Enzymes, Inhibitors, and Substrates DNA metabolism DNA Synthesis Inhibitors Enzyme Inhibitors Enzyme Inhibitors by Type Complex Molecules AMINOPTERIN AMINOPTERINE 4-AMINO-PGA 4-AMINOFOLIC ACID 4-AMINOPTEROYLGLUTAMIC ACID 4-AMINOPTEROYL-L-GLUTAMIC ACID 54-62-6 Biochemicals and Reagents BioChemical Asymmetric Synthesis Apoptosis and Cell Cycle Chiral Building Blocks Cell Biology Cell Signaling and Neuroscience AMINOPTERIN CELL CULTURE TESTED AMINOPTERIN (50X) HYBRI-MAXGAMMA-IRRADIA TED AMINOPTERIN 2-HYDRATE AMINOPETERIN C19H20N8O5 4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA
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