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| CAS No. | 2353-33-5 |
| Chemical Name: | 5-Aza-2'-deoxycytidine |
| Synonyms: | Dacogen;5-AZA-DC;5-AZA-CDR;DECITABINE;NSC 127716;5-azadeoxycytidine;Decitabine(NSC127716);5-DEOXY-2'-AZACYTIDINE;2'-DEOXY-5-AZACYTIDINE;5-AZA-2'-DEOXYCYTIDINE |
| CBNumber: | CB6284800 |
| Molecular Formula: | C8H12N4O4 |
| Formula Weight: | 228.21 |
| MOL File: | 2353-33-5.mol |
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| 5-Aza-2'-deoxycytidine Property |
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| solubility : |
acetic acid/water (1:1): 50 mg/mL
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| Stability:: |
Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. |
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5-Aza-2'-deoxycytidine Chemical Properties,Usage,Production |
Chemical Properties
white crystalline powder |
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Usage
Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. |
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Usage
Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively |
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General Description
Fine white crystalline powder. Used as a drug. |
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Air & Water Reactions
Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour . |
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Reactivity Profile
5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
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Fire Hazard
Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible. |
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Biological Activity
Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. |
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| 5-Aza-2'-deoxycytidine Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| 5-Aza-2'-deoxycytidine Suppliers Global( 201)Suppliers |
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4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on
4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one
5-azadeoxycytidine
5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3
Gene Regulation and Expression
Gene Regulation
Nucleosides, Nucleotides, Oligonucleotides
Nucleoside Analogs
2353-33-5
2'-DEOXY-5-AZACYTIDINE
Biochemicals and Reagents
BioChemical
Cell Biology
Cell Signaling and Neuroscience
4-AMINO-1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-1,3,5-TRIAZIN-2(1H)-ONE
5-AZA-2'-DEOXYCYTIDINE
5-AZA-CDR
5-AZA-DC
5-DEOXY-2'-AZACYTIDINE
DECITABINE
2'-desoxy-5-azacytidine
4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
5-Aza-2-Deoxy-B-D-Cytidine99%
C8H12N4O4
5-Aza-2'-deoxy-D-cytidine
5’-Azido-2’-deoxycytidine
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-
Dacogen
NSC 127716
s-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)- (7CI,8CI)
5-AZA-2''-DEOXYCYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM
API
Decitabine for research
Bases & Related Reagents
Nucleotides
2μ-Deoxy-5-azacytidine, Decitabine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
s-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-amino-1,3,5-triazine-2(1H)-one
4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
5-Aza-2'-deoxycytidine,98+%
4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
analog of cytosine
Decitabine(NSC127716)
Decitabine(5-aza-2'-deoxycytidine,NSC127716)
5-Aza-2'-deoxycytidine (Decitabine)
2353-55-5
Intermediates & Fine Chemicals
Pharmaceuticals
5-Aza-2zzhlxy-deoxycytidine (Decitabine)
4-aMino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
4-aMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one
Epigenetics
Decitabine (NSC127716, 5AZA-CdR)
Inhibitor
Deoxycytidine
Anti-cancer&immunity
5-Aza-2'-deoxycytidine
4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
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