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| CAS-Nr. | 745055-91-8 |
| Bezeichnung: | |
| Englisch Name: | (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE |
| Synonyma: |
UBP 302;(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE;(αS)-α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid |
| CBNumber: | CB8428312 |
| Summenformel: | C15H15N3O6 |
| Molgewicht: | 333.3 |
| MOL-Datei: | Mol file |
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| (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE physikalisch-chemischer Eigenschaften |
| storage temp. : |
Store at RT |
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(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemische Eigenschaften,Einsatz,Produktion Methoden |
Biologische Aktivit?t
Selective and potent GLU K5 (GluR5)-subunit containing kainate receptor antagonist (apparent K D = 402 nM); active enantiomer of UBP 296 ((RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione ). Displays ~ 260-fold selectivity over AMPA receptors. UBP 296 displays ~ 90-fold selectivity over recombinant human GLU K6 - and GLU K2 -containing kainate receptors, has little or no action at NMDA or group I mGlu receptors and selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres. |
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| (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Upstream-Materialien And Downstream Produkte |
Upstream-Materialien
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Downstream Produkte
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| (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global( 4)Lieferanten |
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