公司名称: |
上海波以尔化工有限公司 |
联系电话: |
Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market) |
产品介绍: |
中文名称:顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸 英文名称:cis-4-(4-Chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexanepropanoic acid CAS:471905-41-6
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公司名称: |
百灵威科技有限公司 |
联系电话: |
400-666-7788 +86-10-82848833 |
产品介绍: |
英文名称:MK-0752 CAS:471905-41-6 包装信息:10Mg,200Mg,50Mg,5Mg 备注:化学试剂、精细化学品、医药中间体、材料中间体 |
公司名称: |
上海佰世凯化学科技有限公司 |
联系电话: |
+86(0)21-20908456 |
产品介绍: |
英文名称:MK-0752 CAS:471905-41-6 备注:C14536 |
公司名称: |
嘉兴市艾森化工有限公司 |
联系电话: |
0573-85280080 18267390595 |
产品介绍: |
中文名称:顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸 CAS:471905-41-6 纯度:98% (HPLC Or GC) 包装信息:25g,100g,500g;1kg |
公司名称: |
济南精合医药科技有限公司 |
联系电话: |
+86 (531) 88811793;+86 (531) 88811783;+(0)18854807083; |
产品介绍: |
英文名称:MK-0752 CAS:471905-41-6 纯度:99% 包装信息:5Mg, 10Mg, 20Mg, 50Mg |
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中文名称: | MK-0752 | 中文同义词: | 顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸 | 英文名称: | MK-0752 | 英文同义词: | cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;MK-0752/MK0752;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid MK-0752 | CAS号: | 471905-41-6 | 分子式: | C21H21ClF2O4S | 分子量: | 443 | EINECS号: | | 相关类别: | 信号转导通路激酶抑制剂;Inhibitor |
生物活性 | MK-0752是一种适度有效的γ-secretase(γ-分泌酶)抑制剂,降低Aβ40产量,IC50为5 nM。Phase 1/2。 | 体外研究 | MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation. | 体内研究 | MK-0752 (240 mg/kg) reduces the generation of newly produced Aβ with 90% decrease of AUV in the brain of rhesus monkeys. In addition, MK-0752 treatment increases levels of Aβ 1-14, Aβ 1-15, and Aβ 1-16 , while decreases levels of Aβ 1-17. In guinea-pigs, oral administration of MK-0752 (10 mg/kg -30 mg/kg) results in the dose-dependent reduction of Aβ40 in plasma, brain and cerebrospinal fluid (CSF) with IC50 of 440 nM in brain. | 特征 | MK-0752 is a moderately potent γ-secretase inhibitor. |
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